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**Efineptakin alfa + atezolizumab** is an investigational combination therapy comprised of efineptakin alfa (NT-I7), a novel long-acting recombinant human interleukin-7 cytokine, and atezolizumab (Tecentriq), a monoclonal antibody targeting programmed death-ligand 1 (PD-L1)[1][3][7]. Efineptakin alfa enhances T-cell amplification and function, potentially improving antitumor immune responses, while atezolizumab blocks PD-L1 to restore and potentiate T-cell-mediated antitumor activity[1][3][7]. The combination is under clinical investigation for advanced or metastatic solid tumors, with focus on high-risk skin cancers (melanoma, Merkel cell carcinoma, cutaneous squamous cell carcinoma) and non-small cell lung cancer (NSCLC)[1][3][5][7].
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