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egaptivon pegol
- Development stage
- Phase 2
- Lead developer
- Takeda
- Modality
- RNA Aptamers → RNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes, DNA Aptamers → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
Egaptivon pegol is a PEGylated DNA aptamer that acts as an antagonist of the A1 domain of von Willebrand factor (vWF), thereby inhibiting its interaction with the platelet glycoprotein Ib (GPIb) receptor. This mechanism blocks vWF-mediated platelet adhesion, activation, and aggregation under high shear conditions, such as those found in coronary arterial stenosis and plaque rupture. Egaptivon pegol was developed for antithrombotic therapy and investigated primarily for thrombotic thrombocytopenic purpura (TTP) and acute coronary syndromes. It is a second-generation aptamer with enhanced properties due to PEGylation[1][2][7].
- Other names
- egaptivon pegol sodium
02
Targets
BB-031 (Von Willebrand factor)
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