Drug intelligence / Profile preview

EGb 761

Development stage
Phase 4
Lead developer
Schwabe
Modality
Small Molecules
Administration
Oral
01

Overview

EGb 761 is a standardized, proprietary extract of the leaves of the Ginkgo biloba tree. It is one of the most extensively studied herbal extracts and contains a defined composition of active constituents, including approximately 24% ginkgoflavone glycosides and 6% terpene trilactones (notably ginkgolides A, B, and bilobalide), with less than 5 ppm ginkgolic acids. The extract exhibits antioxidant properties and neuroprotective effects by scavenging free radicals, modulating neurotransmitter systems (including dopamine), improving microcirculation through vasoregulatory actions, inhibiting platelet activating factor (PAF), and reducing neuronal damage from beta amyloid toxicity. Clinically, EGb 761 has been shown to be effective in symptomatic treatment of cognitive impairment and dementia (including Alzheimer's disease), tinnitus, vertigo, anxiety disorders, premenstrual syndrome symptoms such as breast tenderness, and possibly post-COVID cognitive deficits. Its efficacy in dementia has been demonstrated in multiple randomized controlled trials using validated cognitive scales[1][3][4][5][7][9][10].

Brand names
RökanTanakanTeboninGinkobaGinkgo-DGinkgold
Other names
Ginkgo biloba extract EGb 761
02

Targets

PTAFR (Platelet-activating factor receptor)DAT (Dopamine plasma membrane transport protein)

Beyond the preview

Go deeper on EGb 761.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on EGb 761.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call