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EGFR-CAR T cells
- Development stage
- Unknown
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
EGFR-CAR T cells are a type of chimeric antigen receptor (CAR) T-cell therapy engineered to target the epidermal growth factor receptor (EGFR) on cancer cells. This specific therapy utilizes the non-viral piggyBac transposon system to introduce the CAR transgene into T cells, offering a simpler and more economical alternative to viral systems. It is being developed for the treatment of advanced relapsed/refractory EGFR-positive non-small cell lung cancer (NSCLC) patients, aiming to assess its safety and feasibility.
- Other names
- EGFR-specific CAR-T cells generated by the piggyBac transposon systempiggyBac-generated EGFR-CAR T cells
02
Targets
EGFRvIII (Epidermal growth factor receptor variant III)EGFR T790M (Epidermal growth factor receptor T790M mutant)
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