Drug intelligence / Profile preview

Egyptian MTA

Development stage
Phase 4
Lead developer
Cairo University
Modality
Small Molecules
Administration
Topical
01

Overview

Egyptian MTA is a bioceramic dental material developed for restorative and endodontic applications, specifically for indirect pulp capping in teeth with deep caries. Developed by researchers at Cairo University and marketed under the brand name Toothmate, it serves as a biocompatible alternative to traditional materials like calcium hydroxide and imported MTA products. The material consists of a powder (primarily tricalcium silicate, dicalcium silicate, and tricalcium aluminate) and a liquid that, when mixed, form a paste that sets in a moist environment. Its mechanism of action involves the release of calcium ions and the creation of an alkaline environment, which promotes the formation of hydroxyapatite and stimulates pulp cells to produce reparative dentin. This process helps maintain pulp vitality and provides a biological seal against bacterial microleakage.

Brand names
Toothmate
Other names
Egyptian Mineral Trioxide Aggregate
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)ALPL (Tissue-nonspecific alkaline phosphatase)BMP2 (Bone morphogenetic protein 2)

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