eicosatetraynoic acid

Eicosatetraynoic acid (ETYA) is a synthetic, non-metabolizable analog of arachidonic acid in which the four double bonds are replaced by triple bonds. It functions as a dual inhibitor of the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, thereby preventing the synthesis of prostaglandins and leukotrienes. Beyond its role in arachidonic acid metabolism, ETYA acts as a pan-agonist for the peroxisome proliferator-activated receptors (PPARα, PPARδ, and PPARγ). In recent research, ETYA has been identified through perturbagen bioinformatics as a potential therapeutic for Crohn's disease, specifically for its ability to regulate mitochondrial and extracellular matrix gene expression. In human intestinal organoid models, ETYA has demonstrated the capacity to reduce tissue stiffness and inhibit pro-fibrotic pathways associated with ileal stricture formation, suggesting a potential role in preventing intestinal fibrosis in patients who are refractory to anti-TNF therapies.

Other names

5,8,11,14-eicosatetraynoic acid