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EIF4G1 shRNA
- Development stage
- Preclinical
- Lead developer
- Louisiana State University Health Sciences Center
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
EIF4G1 shRNA is an experimental RNA-based therapeutic candidate designed to silence the expression of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1). EIF4G1 serves as a critical scaffold protein for the eIF4F translation initiation complex, which is frequently deregulated in various cancers to facilitate the translation of oncogenic mRNAs. In preclinical research, particularly in models of enzalutamide-resistant prostate cancer, the use of shRNA to knockdown EIF4G1 has been shown to impair tumor cell proliferation, viability, migration, and invasion, as well as inhibit prostasphere formation. This approach aims to overcome therapeutic resistance by targeting the fundamental translation machinery required for cancer progression.
- Other names
- shRNA targeting EIF4G1
02
Targets
EIF4G1 (Eukaryotic translation initiation factor 4 gamma 1)
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