Drug intelligence / Profile preview

EIK1001 + pembrolizumab + paclitaxel + carboplatin

Development stage
Phase 3
Lead developer
Eikon Therapeutics
Modality
Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

A combination regimen comprised of **EIK1001**, **pembrolizumab**, **paclitaxel**, and **carboplatin**, investigated primarily as an antineoplastic therapy in oncology clinical trials. - **Pembrolizumab** is a monoclonal antibody checkpoint inhibitor targeting the programmed cell death protein 1 (PD-1), enhancing T-cell-mediated immune responses against tumors. - **Paclitaxel** is a microtubule-stabilizing chemotherapeutic agent that disrupts mitosis, leading to apoptosis in rapidly dividing cancer cells. - **Carboplatin** is a platinum-containing chemotherapeutic agent that forms DNA crosslinks, inhibiting DNA replication and leading to cell death. - **EIK1001** is a candidate drug whose specific mechanism and developer are currently unconfirmed in public databases. The combination is under investigation for solid tumors, leveraging immunotherapy with established chemotherapeutic backbones.

02

Targets

DNAPDCD1 (Programmed cell death protein 1 receptor)TLR7 (Toll-like receptor 7)TLR8 (Toll-like receptor 8)TUBB (Tubulin (alpha and beta subunits))

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