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**ELAD** is a discontinued proprietary bioartificial, extracorporeal liver-support system developed for acute forms of liver failure. The system used a dialysis-type circuit with four hollow-fiber bioreactor cartridges containing more than 100 billion HepG2/C3A human hepatoblastoma-derived cells. Patient plasma was circulated through the device to provide temporary hepatocyte-like metabolic, synthetic, detoxification, and immunomodulatory support, including secretion of anti-inflammatory proteins and growth factors, with the intended role of bridging patients to native liver recovery or liver transplantation. ELAD did not act through a defined molecular binding target. ([dovepress.com](https://www.dovepress.com/article/download/42372))
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