elasomeran

Elasomeran is a single-stranded, 5'-capped messenger RNA (mRNA) vaccine produced using a cell-free in vitro transcription from corresponding DNA templates. It encodes the viral spike (S) protein of SARS-CoV-2 (original strain), modified with 2 proline substitutions within the heptad repeat 1 domain (S-2P) to stabilize the spike protein into a prefusion conformation. After intramuscular injection, cells at the injection site and draining lymph nodes take up the lipid nanoparticle, delivering the mRNA sequence into cells for translation into viral spike protein. The delivered mRNA does not enter the cellular nucleus or interact with the genome, is non-replicating, and is expressed transiently. The expressed, membrane-bound spike protein of SARS-CoV-2 is then recognized by immune cells as a foreign antigen, stimulating an immune response to prevent COVID-19.

Brand names

SpikevaxMODERNA COVID-19 VACCINE

Other names

COVID-19 mRNA vaccineCOVID19 mRNA vaccineCOVID 19 mRNA vaccineAndusomeran