elcatonin

Elcatonin is a synthetic derivative of eel calcitonin, modified by replacing the disulfide bond between cysteine residues at positions 1 and 7 with an ethylene (C-N) bond, resulting in increased physio-chemical stability. It acts primarily as an anti-resorptive agent by binding to calcitonin receptor on osteoclasts, thereby inhibiting their activity and reducing bone resorption. Elcatonin also inhibits renal reabsorption of calcium, phosphorus, and sodium, helping maintain normal blood calcium levels. Clinically, it is used for the treatment of osteoporosis (especially postmenopausal), Paget's disease of bone, hypercalcemia, and for alleviating pain associated with osteoporosis or fractures. Its mechanism involves suppression of osteoclast differentiation from preosteoclasts and modulation of signaling pathways such as adenylyl cyclase-cAMP via NO- and COX-dependent mechanisms[1][4][5][6][7][8].

Other names

elcatonina