eledoisin

Eledoisin is a naturally occurring undecapeptide (11 amino acids) neuropeptide of the tachykinin family, originally isolated from the posterior salivary glands of Mediterranean octopuses (*Eledone moschata* and *E. aldovandi*)[4][8]. It acts as a potent agonist at neurokinin receptors, especially NK1 and NK2, mediating smooth muscle contraction and sensory neurotransmission[1][4]. Eledoisin exhibits pharmacological activities such as vasodilation, increased capillary permeability, stimulation of extravascular smooth muscle contraction, and modulation of ion transport in certain tissues[4][6][8]. Its sequence is pGlu-Pro‑Ser‑Lys‑Asp‑Ala‑Phe‑Ile‑Gly‑Leu‑Met-NH2. While it has been widely used in research to study tachykinins and their receptors due to its availability before mammalian tachykinins were characterized, it is not approved for clinical use in humans[5][6].

Other names

eledoisin [inn]eledoisinumeledoisinaeledoisineeledoisine [inn-french]eledoisina [inn-spanish]