ELP-KLAK

ELP-KLAK is a genetically engineered fusion protein consisting of an elastin-like polypeptide (ELP) carrier conjugated to the pro-apoptotic peptide (KLAKLAK)2. ELPs are thermal-responsive biopolymers derived from human elastin that undergo a phase transition at a specific temperature, allowing the construct to self-assemble into nanoparticle-like structures at physiological body temperature. This self-assembly enhances the stability and pharmacokinetic profile of the (KLAKLAK)2 peptide, which is a synthetic amphipathic α-helical peptide designed to selectively disrupt mitochondrial membranes. Upon internalization, the (KLAKLAK)2 payload triggers the release of cytochrome c and initiates the apoptotic cascade. ELP-KLAK has been investigated in preclinical models for various cancers, including breast cancer and melanoma, often serving as a non-targeted control for more complex constructs like AP1-ELP-KLAK, which incorporates targeting ligands for the IL-4 receptor.

Other names

elastin-like polypeptide-KLAKLAK2