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ELQ-596
- Development stage
- Preclinical
- Lead developer
- Drexel University, College of Medicine
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
ELQ-596 is a second-generation 3-biaryl endochin-like quinolone (ELQ) small molecule antimalarial and antiparasitic agent. It targets the mitochondrial electron transport chain of various human parasites, specifically acting as an inhibitor of the Qi site of the cytochrome bc1 complex (cytochrome b). Developed by Oregon Health & Science University, Drexel University College of Medicine, and the VA Portland Healthcare System, ELQ-596 exhibits low- to sub-nanomolar potency against multidrug-resistant strains of Plasmodium falciparum and has shown promising activity against Babesia species (such as Babesia duncani and Babesia microti). It is designed for long-duration protection against malaria, with potential for once-monthly oral prophylaxis. An alkoxycarbonate ester prodrug of ELQ-596, known as ELQ-598, is also under development to improve solubility and reduce crystallinity.
- Other names
- 3-biaryl endochin-like quinolone 596endochin-like quinolone 596
02
Targets
CYTB (Plasmodium falciparum cytochrome bc1 complex (qi site))
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