Drug intelligence / Profile preview

elvitegravir

Development stage
Approved
Lead developer
Gilead Sciences
Modality
Small Molecules
Administration
Oral
01

Overview

Elvitegravir is an antiretroviral drug used in combination with other agents for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. It acts as an integrase strand transfer inhibitor (INSTI), blocking the HIV-1 integrase enzyme that is essential for viral replication. By inhibiting this enzyme, elvitegravir prevents the integration of viral DNA into the host genome, thereby halting propagation of HIV within the body. Elvitegravir was developed by Gilead Sciences and was originally licensed from Japan Tobacco[2][5]. It is indicated primarily for use in adults who have previously received antiretroviral therapy[8].

Brand names
GenvoyaStribildVitekta
Other names
elvitegravir
02

Targets

Integrase allosteric pocket (HIV)

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