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Drug intelligence / Profile preview
emtricitabine + rilpivirine + tenofovir disoproxil fumarate
- Development stage
- Approved
- Lead developer
- Gilead Sciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Emtricitabine + rilpivirine + tenofovir disoproxil fumarate is a once-daily, oral fixed-dose antiretroviral combination for treatment of **human immunodeficiency virus type 1 infection**. It combines emtricitabine, a nucleoside reverse transcriptase inhibitor; tenofovir disoproxil fumarate, an orally bioavailable prodrug of the nucleotide reverse transcriptase inhibitor tenofovir; and rilpivirine, a non-nucleoside reverse transcriptase inhibitor. The three agents inhibit HIV-1 reverse transcriptase through complementary active-site and allosteric mechanisms, suppressing viral replication. It is marketed by Gilead as Complera in the United States and Eviplera in Europe. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d637cfab-f1e8-4eb3-a1b3-f85ca3bec612))
- Brand names
- CompleraEviplera
- Other names
- emtricitabine + rilpivirine + tenofovir disoproxilemtricitabine/rilpivirine/tenofovir disoproxilemtricitabine/rilpivirine/tenofovir disoproxil fumarateFTC/RPV/TDFFTC/RPV/TFVrilpivirine/emtricitabine/tenofovir disoproxil fumarateRPV/FTC/TDFTDF/FTC/RPV
02
Targets
Human immunodeficiency virus type 1 reverse transcriptase
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