Drug intelligence / Profile preview

EMZ702 + pegylated interferon + ribavirin

Development stage
Preclinical
Lead developer
SciClone Pharmaceuticals
Modality
Peptides, Small Molecules, Recombinant Proteins and Enzymes
Administration
Subcutaneous, Oral
01

Overview

EMZ702 + pegylated interferon + ribavirin is an investigational combination drug regimen for the treatment of chronic hepatitis C. **EMZ702** is a non-toxic agent, chemically synthesized, that shows strong anti-viral synergy when combined with interferon-based therapies. In preclinical models, **EMZ702** combined with pegylated interferon and ribavirin produced a two to threefold increase in anti-viral potency versus standard pegylated interferon plus ribavirin. **Pegylated interferon** is an engineered form of interferon alpha with increased bioavailability and extended half-life, making it suitable for weekly subcutaneous injections. **Ribavirin** is a nucleoside analog antiviral. The combination targets viral replication and modulates the host immune response, with substantial evidence from clinical trials and surrogate models supporting efficacy especially in hepatitis C virus (HCV) infections[1][2][8]. The regimen is under development and does not have a unique brand name or commercial manufacturer associated with the combination; EMZ702 is sometimes referenced as thymalfasin (thymosin alpha 1), which is approved in some countries[1].

02

Targets

NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)IFNAR (Immune system modulation via type I interferon receptor)

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