Drug intelligence / Profile preview

enalapril + lercanidipine

Development stage
Unknown
Lead developer
KRKA
Modality
Small Molecules
Administration
Oral
01

Overview

**Enalapril + lercanidipine** is an oral fixed-dose antihypertensive combination of enalapril, an angiotensin-converting enzyme inhibitor prodrug, and lercanidipine, a dihydropyridine calcium-channel blocker. Enalapril is converted to enalaprilat and reduces angiotensin II formation, while lercanidipine inhibits L-type calcium-channel-mediated vascular smooth-muscle contraction; together these complementary actions lower peripheral vascular resistance and blood pressure. The combination was developed by Recordati and is marketed in multiple countries for essential hypertension, generally when blood pressure is insufficiently controlled with enalapril alone. ([recordati.com](https://recordati.com/wp-content/uploads/2023/06/slides-32-1-1.pdf))

Brand names
AtoverCarmen ACECoriprenElernapElyrnoEnacanpinLecorin ACELercanil ACELercapin ACELercaprelLercapressLercarilLerpinLertecTansiprexVasodip ComboZanicomboZanidualZanerilZanextraZanipressZaniprilZanitek
Other names
enalapril + lercanidipineenalapril maleate + lercanidipine hydrochlorideenalapril maleate / lercanidipineenalapril/lercanidipinelercanidipine + enalapril
02

Targets

ACE (Angiotensin Converting Enzyme)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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