enalapril + clonidine

Enalapril + clonidine is a combination of two antihypertensive drugs: enalapril, an angiotensin-converting enzyme (ACE) inhibitor, and clonidine, a centrally acting alpha-2 adrenergic agonist. **Enalapril** acts primarily by inhibiting the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and lowering blood pressure. **Clonidine** works by stimulating central alpha-2 adrenoceptors, leading to decreased sympathetic outflow, which reduces peripheral vascular resistance and lowers blood pressure. Together, this combination may be used in the management of hypertension when monotherapy is insufficient, although this is not a commonly marketed fixed-dose combination.