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Enalapril + folic acid is a fixed-dose combination therapy used primarily for the management of hypertension and reduction of stroke risk in certain populations. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by suppressing the renin-angiotensin-aldosterone system, leading to vasodilation and reduced vascular resistance. Folic acid, a B-vitamin, helps lower homocysteine levels—a risk factor for cardiovascular disease—and may provide additional vascular protection. Clinical studies have shown that this combination can reduce the risk of first stroke in hypertensive patients, particularly those with elevated homocysteine or low platelet count[2][3][8]. The combination has also demonstrated beneficial effects on fasting plasma glucose in hypertensive patients with hyperglycemia[1], as well as protective effects against renal injury through antioxidative and endothelial function-promoting mechanisms[5].
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