Drug intelligence / Profile preview

enalapril maleate + nitrendipine

Development stage
Unknown
Lead developer
Grupo Vita
Modality
Small Molecules
Administration
Oral
01

Overview

**Enalapril maleate + nitrendipine** is an oral fixed-dose antihypertensive combination containing enalapril maleate 10 mg and nitrendipine 20 mg per tablet. Enalapril is a prodrug converted to enalaprilat, which inhibits angiotensin-converting enzyme and reduces angiotensin II formation and aldosterone signaling. Nitrendipine is a dihydropyridine calcium-channel blocker that inhibits L-type voltage-dependent calcium channels in vascular smooth muscle, producing arterial vasodilation. The complementary mechanisms lower blood pressure in adults with essential hypertension that is inadequately controlled with either component alone. It was developed and marketed by Ferrer and is supplied as an immediate-release oral tablet. ([cima.aemps.es](https://cima.aemps.es/cima/dochtml/ft/64505/FichaTecnica_64505.html))

Brand names
BaroprineCenipresEneasEnitVipres
Other names
enalapril + nitrendipineenalapril maleate/nitrendipineenalapril/nitrendipinenitrendipine + enalapril maleatenitrendipine/enalapril
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)ACE (Angiotensin Converting Enzyme)

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