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Enantia chlorantha extract
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Enantia chlorantha extract is a botanical extract derived from the stem bark of the Enantia chlorantha Oliv. tree (also known as Annickia chlorantha), which is native to West and Central Africa. Traditionally used in African folk medicine to treat malaria, jaundice, typhoid fever, and urinary tract infections, the extract contains bioactive constituents such as protoberberine alkaloids (including palmatine, columbamine, and jatrorrhizine), saponins, flavonoids, and phenols. Preclinical studies have demonstrated that the extract possesses antiplasmodial, antimicrobial, antioxidant, anti-inflammatory, analgesic, and antipyretic properties. Additionally, it has been investigated for its cytotoxic activity against certain cancer cell lines and is utilized in cosmetic formulations for sebum regulation and pore refinement.
- Other names
- Annickia chlorantha extractEnantia chlorantha bark extractEnantia chlorantha stem bark extract
02
Targets
Topo IV (Bacterial Topoisomerase IV)BEP (Bacterial efflux pump system)Neuraminidase
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