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ENC-101-hPTG

Development stage: Preclinical
Lead developer: Encellin
Modality: Cell Therapies
Administration: Implant, Subcutaneous

Overview

ENC-101-hPTG is an investigational encapsulated cell therapy being developed by Encellin for the treatment of severe refractory hypoparathyroidism. The therapy utilizes Encellin's proprietary Encapsulated Cell Replacement Therapy (ENCRT) platform, which consists of a nanoporous, immunoprotective, and pro-angiogenic membrane pouch. This pouch is loaded with primary human parathyroid gland (PTG) cells. Once implanted subcutaneously, the device is designed to protect the allogeneic parathyroid cells from host immune rejection and fibrosis while allowing the free exchange of nutrients, calcium, and parathyroid hormone (PTH). By restoring physiological PTH secretion, ENC-101-hPTG aims to regulate systemic calcium homeostasis without requiring lifelong immunosuppression or daily hormone injections.

Other names: ENC 10x xPTGENC10x xPTGENC-10x xPTG

Targets

PTH1R (Parathyroid hormone/Parathyroid hormone-related peptide receptor type 1)CaSR (Extracellular calcium-sensing receptor)

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