Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
EncorStat
- Development stage
- Unknown
- Lead developer
- Oxford BioMedica
- Modality
- Adult Stem Cells → Stem Cell Therapies → Cell Therapies, Tissue Cells → Other Cell Types → Cell Therapies, Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Ophthalmic
01
Overview
EncorStat is an ex vivo gene-modified human donor corneal graft product (OXB-202) being developed to prevent corneal graft rejection in high‑risk keratoplasty. It uses a LentiVector-based gene therapy to transduce donor corneal tissue before transplantation with genes encoding secretable forms of the angiostatic and immunomodulatory proteins endostatin and angiostatin, aiming to inhibit neovascularization and dampen alloimmune responses that drive rejection. Developed by Oxford BioMedica, EncorStat is intended as a one‑time modification of donor corneas at the tissue bank or surgical center, preserving tissue transparency and biomechanical integrity while providing long‑term local expression of anti‑angiogenic factors to improve graft survival in patients at high risk of rejection.[9][11][13][15]
- Brand names
- EncorStat
- Other names
- OXB-202OXB202OXB 202
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)
Beyond the preview
Go deeper on EncorStat.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on EncorStat.