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Endomethasone N
- Development stage
- Unknown
- Lead developer
- Septodont
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical (intracanal, Dental)
01
Overview
Endomethasone N is a zinc oxide–eugenol-based root canal sealer containing hydrocortisone acetate (1%), barium sulfate, magnesium stearate, and thymol iodide, developed by Septodont for use in endodontic procedures. The hydrocortisone acetate acts as an anti-inflammatory agent by diffusing through the root apex after endodontic treatment, reducing pro-inflammatory cytokines (such as Interleukin-6 and TNFα) and decreasing the adhesion and migration of inflammatory cells, thereby lowering both spontaneous and masticatory post-endodontic pain. The formulation is radiopaque (due to barium sulfate) and designed for permanent root canal filling and sealing, with effective sealing and dimensional stability[1][3][5].
- Brand names
- Endomethasone N
- Other names
- EndoN
02
Targets
GR (Glucocorticoid receptor)
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