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engineered Lactobacillus reuteri
- Development stage
- Unknown
- Lead developer
- Shenzhen People's Hospital
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
Engineered Lactobacillus reuteri is a live biotherapeutic product being investigated for the topical treatment of acne. [4] It consists of the probiotic Lactobacillus reuteri which has been modified with a special coating formed by zinc sulfate and tannic acid (a metal-polyphenol network or MPN coating). [4, 9] This engineering is intended to enhance the bacterium's survival and colonization on the skin. [4] The proposed mechanism of action is the modulation of the local skin microecology to restore microbial balance, which in turn is expected to reduce inflammation associated with acne. [4] It is being developed by Shenzhen People's Hospital and is under evaluation in a Phase 2 clinical trial for Grade I to III acne. [2, 4, 9]
- Other names
- engineered Lactobacillus reuteri with a zinc sulfate-tannic acid MPN coating
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