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engineered nasal cartilage graft
- Development stage
- Phase 1
- Lead developer
- University Hospital Basel
- Modality
- Cell Therapies
- Administration
- Implant
01
Overview
The engineered nasal cartilage graft is an autologous, tissue-engineered biologic developed by the University Hospital Basel for the reconstruction of nasal alar lobule defects following the resection of non-melanoma skin cancer. The product is created by isolating autologous nasal chondrocytes from a patient's septal biopsy, expanding them ex vivo, and seeding them onto a collagen type I and type III membrane scaffold. This construct is cultured to form a functional cartilage graft that is then surgically shaped and implanted into the defect. In a Phase I clinical trial (NCT01242618), the graft demonstrated safety and feasibility, providing satisfactory aesthetic and functional outcomes in elderly patients.
- Other names
- tissue engineered nasal cartilageautologous nasal cartilage graftengineered autologous nasal cartilage graft
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