Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Enhanced regimen (Mansoura University)
- Development stage
- Phase 4
- Lead developer
- Mansoura University
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
The Enhanced regimen is a specific preoperative antibiotic prophylaxis protocol developed by Mansoura University for patients undergoing retrograde intrarenal surgery (RIRS) who are at high risk for infectious complications. The regimen consists of a short-course (2-day) administration of antibiotics, primarily utilizing sulfamethoxazole-trimethoprim (TMP-SMX) twice daily, with the final dose administered one day prior to surgery. In instances of patient allergy or bacterial resistance, the protocol allows for the use of nitrofurantoin, ciprofloxacin, or cefpodoxime as alternatives. This regimen is currently being evaluated in a Phase 3 randomized controlled trial against an Extended regimen (7-day course) to determine its efficacy in preventing postoperative urosepsis and other infections while potentially reducing overall antibiotic exposure.
- Other names
- Enhanced regimen2-day preoperative antibiotic prophylaxis
02
Targets
DHFR (Dihydrofolate reductase)DHPS (Dihydropteroate synthase)
Beyond the preview
Go deeper on Enhanced regimen (Mansoura University).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Enhanced regimen (Mansoura University).