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eniluracil + fluorouracil + paclitaxel
- Development stage
- Unknown
- Lead developer
- Processa Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination chemotherapy regimen consisting of eniluracil, fluorouracil (5-FU), and paclitaxel. Eniluracil is a potent inactivator of dihydropyrimidine dehydrogenase (DPD), which allows for oral administration of 5-FU with predictable bioavailability. This combination has been studied in clinical trials for the treatment of metastatic breast cancer, particularly in patients with taxane-resistant disease.
02
Targets
MicrotubuleDPYD (Dihydropyrimidine dehydrogenase)TS (Thymidylate synthase)
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