enkephalin

Enkephalin (marketed in China under the brand name Enruike or Enrikefon) is an endogenous opioid pentapeptide, specifically leucine-enkephalin, used for the management of postoperative pain and postoperative fatigue syndrome (POFS). Developed by Shenyang Enrikefon Pharmaceutical, the drug acts as an agonist at delta-opioid and mu-opioid receptors, providing analgesic effects and potentially mitigating the physiological stress response associated with surgery. It is often utilized as part of a multimodal analgesia strategy to enhance recovery and reduce the incidence of fatigue in patients following major surgical procedures, such as thoracoscopic lung resection. Enkephalin is approved in China and has been evaluated in various clinical settings to optimize perioperative care.

Brand names

EnruikeEnrikefon

Other names

leucine-enkephalinLeu-enkephalin恩克法林