Drug intelligence / Profile preview

ENOB-HV-21

Development stage
Discontinued
Lead developer
Enochian Biosciences
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

**ENOB-HV-21** is an investigational, HIV-directed adaptive allogeneic cell-therapy program originating from proprietary technology licensed from Seraph Research Institute. Public program descriptions characterize it as an allogeneic natural killer-cell and gamma delta T-cell approach intended to treat or potentially cure HIV infection. Enochian BioSciences completed an investigator-initiated Pre-IND process in October 2021, but subsequently deprioritized the program and was not actively pursuing clinical development. The precise cell-engineering methods, product composition, manufacturing process, administration route, and molecular targets have not been publicly disclosed. ([sec.gov](https://www.sec.gov/Archives/edgar/data/1527728/000173112223000271/e4443_10k.htm))

Other names
Adaptive allogeneic cell therapyAllogeneic NK and gamma delta T-cell therapyENOB HV 21

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