Drug intelligence / Profile preview

enoxaparin + folic acid

Development stage
Unknown
Lead developer
Assiut University
Modality
Small Molecules
Administration
Subcutaneous, Oral
01

Overview

Enoxaparin + folic acid is an investigational combination regimen studied for the prevention of recurrent miscarriage in women who test negative for antiphospholipid antibodies. The regimen consists of enoxaparin, a low molecular weight heparin (LMWH) that acts as an anticoagulant by accelerating the activity of antithrombin III to inhibit Factor Xa and thrombin, and folic acid, a B-vitamin essential for DNA synthesis and homocysteine regulation. This combination was evaluated in a randomized controlled trial led by researchers at Assiut University, which demonstrated improved pregnancy outcomes compared to folic acid alone, suggesting that LMWH may benefit women with unexplained recurrent miscarriage by addressing potential subclinical thrombotic issues or placental vascular complications.

Other names
LMWH + folic acidlow molecular weight heparin + folic acid
02

Targets

ATIII (Antithrombin III)Coagulation Factor IXaFOLR1 (FRα)F2 (Thrombin)F10 (Factor Xa)

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