ensereptide

Ensereptide (PXL01) is a synthetic peptide derived from human lactoferrin, an iron-binding glycoprotein found in milk and mucosal secretions. It is being developed primarily for the prevention of post-surgical adhesions, particularly after tendon repair surgery in the hand, and for the prevention of dermal scarring after surgery or trauma. The drug acts through several mechanisms including immunomodulation—by inhibiting pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α—and enhancement of fibrinolytic activity by inhibiting plasminogen activator inhibitor-1 (PAI-1). These actions reduce inflammation and promote fibrinolysis at surgical sites to prevent adhesion formation and scar tissue development. Ensereptide is typically formulated with sodium hyaluronate as a carrier to provide local delivery and sustained release at the site of injury[1][3][4][5][7].

Other names

ensereptide