ent-verticilide

ent-verticilide is a synthetic 24-membered cyclooligomeric depsipeptide that is the enantiomer of the natural fungal product nat-(-)-verticilide. It acts as a potent and selective inhibitor of the type 2 ryanodine receptor (RyR2), specifically targeting the pathological diastolic calcium leak from the sarcoplasmic reticulum. By stabilizing RyR2 and reducing spontaneous calcium release, ent-verticilide demonstrates antiarrhythmic properties and has shown efficacy in preclinical models of catecholamine-induced ventricular arrhythmias, atrial fibrillation, and hypertrophic cardiomyopathy-related diastolic dysfunction. The compound is primarily being investigated by researchers at Vanderbilt University.

Other names

ent-(+)-verticilide