Drug intelligence / Profile preview

ENU200

Development stage
Preclinical
Lead developer
Ennaid Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

**ENU200** is a repurposed, patent-pending, orally deliverable **small-molecule antiviral** being developed by **Ennaid Therapeutics** for treatment of **asymptomatic, mild to moderate COVID-19**. Public descriptions indicate that it was previously approved by the FDA for a different indication, but the underlying active ingredient and original marketed name have not been publicly disclosed. Ennaid reported that in silico and AI-enabled discovery work identified ENU200 as a candidate with activity against **SARS-CoV-2 spike glycoprotein** and the viral **main protease**, supporting development as an oral, at-home therapy; **Catalent** partnered with Ennaid to develop a **powder-in-capsule** clinical-trial formulation.

Other names
repurposed drug oral COVID-19Ennaid Therapeutics SARS-CoV-2 S glycoprotein protease protein inhibitor
02

Targets

SARS-CoV-2 spikeMpro (3C-like proteinase of SARS-CoV-2)

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