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Env-C Plasmid DNA
- Development stage
- Phase 1
- Lead developer
- Vaccine Research Center
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular
01
Overview
Env-C plasmid DNA is an investigational DNA vaccine designed to induce immune responses against HIV-1 by encoding the envelope glycoprotein (Env) from clade C of the virus. The vaccine consists of a circular plasmid containing the gene for the HIV-1 clade C envelope protein, which is delivered intramuscularly. Once inside host cells, the encoded antigen is expressed and presented to the immune system, aiming to elicit both humoral and cellular immunity. This approach leverages mechanisms such as activation of pattern recognition receptors (e.g., TLR9), leading to innate immune stimulation and subsequent adaptive responses[6]. Env-C plasmid DNA has been studied in prime/boost regimens with protein vaccines and various adjuvants (such as ALF43), primarily for prevention of HIV infection[2][4][8]. The platform relies on in vivo expression of antigens following delivery, with immunogenicity enhanced by codon optimization and advanced delivery methods. **Developers:** Vaccine Research Center
02
Targets
Env (HIV-1 envelope glycoprotein)HIV-1 Envelope glycoprotein-derived peptide–MHC class I complexgp41 (Human immunodeficiency virus type 1 glycoprotein 41)
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