Drug intelligence / Profile preview

envonalkib

Development stage
Phase 3
Lead developer
Chia Tai-Tianqing Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

Envonalkib is a novel, potent small molecule inhibitor of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is designed for the treatment of ALK-positive non-small cell lung cancer (NSCLC), where it has demonstrated significant efficacy, including improved progression-free survival and central nervous system activity compared to first-generation ALK inhibitors such as crizotinib. Envonalkib acts by selectively inhibiting the ALK tyrosine kinase, thereby blocking downstream signaling pathways that drive tumor growth in cancers harboring ALK rearrangements. The drug was developed by Chia Tai Tianqing Pharmaceutical Group and is marketed under the brand name Anluoqing in China for late-stage or metastatic NSCLC[2][4][5][6][7].

Brand names
Anluoqing
Other names
Envonalkib citrate
02

Targets

ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)MET (Mesenchymal-epithelial transition factor receptor)

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