Drug intelligence / Profile preview

Enzepi

Development stage
Unknown
Lead developer
Allergan
Modality
Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

Enzepi is a pancreatic enzyme replacement therapy (PERT) containing pancrelipase, a mixture of digestive enzymes including lipases, proteases, and amylases derived from porcine pancreatic glands. It is indicated for the treatment of exocrine pancreatic insufficiency (EPI) associated with cystic fibrosis, chronic pancreatitis, pancreatic cancer, or post-pancreatectomy. Developed by Allergan (now part of AbbVie), Enzepi replaces deficient endogenous enzymes to facilitate the digestion and absorption of fats, proteins, and carbohydrates. The drug is formulated as gastro-resistant capsules to protect the enzymes from gastric acid, ensuring their release in the small intestine where they exert their catalytic effects.

Brand names
EnzepiZenpep
Other names
pancrelipasepancreas powder
02

Targets

AMY (Pancreatic alpha-amylase)GehA (Triacylglycerol lipase GehA)

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