Ep-475

Ep-475 is a synthetic analog of the thiol proteinase inhibitor E-64. It acts as a potent and selective inhibitor of lysosomal cysteine proteases (thiol proteinases), particularly targeting lysosomal protein degradation pathways. In preclinical studies using isolated rat hepatocytes, Ep-475 was shown to inhibit up to 70% of lysosomal protein degradation at concentrations that do not disturb overall protein synthesis. Additionally, it has demonstrated the ability to reverse calcium-dependent alterations in erythrocyte membranes induced by calcium and calcium activated neutral protease (CANP), suggesting potential utility in modulating red blood cell membrane stability and function[4][5]. There is no evidence that Ep-475 has been developed for clinical use or entered human trials.

Other names

Ep-475Ep475Ep 475