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EP80061
- Development stage
- Preclinical
- Lead developer
- Endotis Pharma
- Modality
- Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Intraperitoneal
01
Overview
EP80061 is a synthetic heparan sulfate (HS) mimetic oligosaccharide developed by Endotis Pharma as a "small-glyco" drug for oncology. It is designed to interfere with the interactions between heparan sulfate proteoglycans and various heparin-binding proteins that drive tumor growth, angiogenesis, and metastasis. Specifically, EP80061 binds to and modulates the activity of growth factors and cytokines including FGF-2, PDGF-BB, VEGF-B, and SDF-1α. In preclinical mouse models, the compound demonstrated significant efficacy in delaying the growth of human rhabdomyosarcoma xenografts and reducing lung metastasis in melanoma models.
02
Targets
FGF2HPSE (Heparanase)PDGFB (PDGF-B)VEGFA (Vascular endothelial growth factor A)CXCL12 (C-X-C motif chemokine ligand 12)VEGFB (Vascular endothelial growth factor B)
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