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Epaloritovorilil is a monoclonal antibody currently under clinical investigation as a second-line systemic therapy for advanced hepatocellular carcinoma (HCC). It is being evaluated in combination with the multi-kinase inhibitor lenvatinib in patients who have either progressed on or are intolerant to prior systemic treatments. The drug is being developed by The Second Affiliated Hospital of Nanchang University, and a prospective, single-arm interventional study (ChiCTR2500113629) has been registered in China to assess its antitumor activity and safety profile in adult patients with advanced HCC.
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