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Drug intelligence / Profile preview
epcoritamab + rituximab + bendamustine
- Development stage
- Phase 2
- Lead developer
- Genmab
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Subcutaneous, Intravenous
01
Overview
**epcoritamab + rituximab + bendamustine** is a combination regimen under investigation for the treatment of follicular lymphoma and other B-cell non-Hodgkin lymphomas. Epcoritamab is a subcutaneously administered, bispecific monoclonal antibody that engages CD3 on T cells and CD20 on B cells, promoting T cell-mediated cytotoxicity against malignant B cells. Rituximab is a monoclonal antibody targeting CD20, leading to B cell depletion via immune-mediated mechanisms. Bendamustine is an alkylating agent causing DNA damage and apoptosis in rapidly dividing cells. Together, these agents provide both targeted immunotherapy and cytotoxic chemotherapy, aiming to maximize anti-tumor efficacy.
- Other names
- epcoritamab + rituximab + bendamustine
02
Targets
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