Drug intelligence / Profile preview

ephedra alata extract

Development stage
Preclinical
Lead developer
University of Jendouba
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ephedra alata extract is a botanical extract derived from the aerial parts, leaves, or fruits of the perennial shrub *Ephedra alata* (commonly known as winged ephedra or alanda), which is native to arid regions of North Africa and the Middle East. The extract contains a variety of bioactive phytochemicals, including ephedrine-type alkaloids (such as pseudoephedrine and ephedrine), flavonoids (such as kaempferol and quercetin), and phenolic acids. It has been traditionally used in folk medicine for respiratory, circulatory, and digestive disorders. In preclinical research, Ephedra alata extract has demonstrated anti-fibrotic, anti-inflammatory, antioxidant, and antimicrobial properties. Specifically, it has been shown to protect against bleomycin-induced pulmonary fibrosis in rats by attenuating oxidative stress, inhibiting profibrotic TGF-β1 signaling, and modulating the gut microbiota via the gut-lung axis.

Other names
alanda extractephedra alata aqueous extractephedra alata decne extractephedra alata decne. extractephedra alata fruit extractephedra alata leaf extractjoint pine extractwinged ephedra extract
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)AMY (Pancreatic alpha-amylase)Sucrase-IsomaltasePNLIP (Pancreatic triacylglycerol lipase)ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)ADRB1 (β1)ADRB2 (β2)ADRB3 (β3)

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