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ephedrine (Pennington Biomedical Research Center)
- Development stage
- Unknown
- Lead developer
- Pennington Biomedical Research Center
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Ephedrine** is a mixed-acting sympathomimetic small molecule evaluated by Pennington Biomedical Research Center in a Phase 2 obesity study, where it was administered with caffeine and studied alone and in combination with pioglitazone. It increases sympathetic adrenergic signaling through direct adrenergic receptor agonism and indirect promotion of norepinephrine release, increasing thermogenesis, energy expenditure, lipolysis, and cardiovascular stimulation. In the obesity trial context, ephedrine plus caffeine was intended to induce uncoupling protein 1 expression and promote weight and fat loss.
- Other names
- ephedrine
02
Targets
ADRB1 (β1)DAT (Dopamine plasma membrane transport protein)ADRB2 (β2)ADRA2A (α2A)SERT (Sodium-dependent serotonin transporter)DRD2 (Dopamine D2 Receptor)NET (Norepinephrine Transporter)ADRA1A (α1A)ADRB3 (β3)
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