Drug intelligence / Profile preview

ephedrine + guaifenesin

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Ephedrine + guaifenesin is an over-the-counter (OTC) combination medication used for the temporary relief of mild symptoms of intermittent asthma, including wheezing, chest tightness, and shortness of breath. It contains two active ingredients: ephedrine, a sympathomimetic amine that acts as a bronchodilator by stimulating alpha and beta-adrenergic receptors to relax bronchial smooth muscle, and guaifenesin, an expectorant that helps thin and loosen bronchial secretions to make coughs more productive. This combination is typically administered as oral tablets. While it provides symptomatic relief, it is not intended for the treatment of severe or persistent asthma. The drug is available as a generic product and is marketed under well-known brand names such as Bronkaid and Primatene Tablets.

Brand names
BronkaidPrimatene Tablets
Other names
ephedrine sulfate + guaifenesinephedrine hydrochloride + guaifenesin
02

Targets

ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)

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