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ephrin-a1
- Development stage
- Preclinical
- Lead developer
- University of Florida
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous, Intratumoral
01
Overview
Ephrin-A1 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein that serves as a high-affinity ligand for the EphA2 receptor tyrosine kinase. In the context of oncology research, particularly for malignant mesothelioma (MM), recombinant ephrin-A1 is investigated for its ability to activate EphA2 signaling. This activation has been shown to induce the expression of microRNA-302b (miR-302b), which subsequently represses the anti-apoptotic gene Mcl-1. By downregulating Mcl-1, ephrin-A1 suppresses tumor cell proliferation and growth, suggesting its potential as a targeted therapeutic agent for cancers characterized by EphA2 overexpression.
- Other names
- EFNA1EFNA-1EFNA 1B61B-61B 61LERK1LERK-1LERK 1EPLG1EPLG-1EPLG 1recombinant-Ephrin-A1recombinant-Ephrin-A-1recombinant-Ephrin-A 1
02
Targets
EPHA1EPHA2 (Ephrin type-A receptor 2)EPHA3 (Ephrin Receptor A3)EPHA4EPHA5
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