ephrinB2-Fc

EphrinB2-Fc is a recombinant fusion protein consisting of the extracellular domain of the EphrinB2 ligand fused to the Fc region of an immunoglobulin (typically human IgG1). It acts as a soluble agonist for the EphB4 receptor, a member of the Eph receptor tyrosine kinase family. The EphrinB2/EphB4 signaling pathway is a critical regulator of vascular development and integrity, specifically involved in the differentiation of arterial and venous endothelial cells and the recruitment of mural cells. Research, notably from the University of California, San Francisco (UCSF), has demonstrated that EphrinB2-Fc can alleviate the severity of brain arteriovenous malformations (bAVMs) by restoring the EphrinB2:EphB4 ratio. In preclinical models, treatment with EphrinB2-Fc has been shown to reduce pathological angiogenesis, increase vascular pericyte and smooth muscle cell coverage, and decrease microhemorrhage and inflammatory gene expression.

Other names

Ephrin-B2-FcEphrin-B-2-FcEphrin-B 2-Fcrecombinant human Ephrin-B2 Fc chimera