Drug intelligence / Profile preview

EpicaPatch

Development stage
Preclinical
Lead developer
Regencor
Modality
Recombinant Proteins and Enzymes
Administration
Topical
01

Overview

**EpicaPatch** is an investigational epicardial regenerative cardiac therapy developed by **Regencor** for use during surgical coronary revascularization, particularly coronary artery bypass grafting after myocardial infarction. It consists of a **compressed bioabsorbable collagen matrix** loaded with **human follistatin-like 1 protein** in a hypoglycosylated or recombinant form and is fixed onto the epicardial surface over the infarct zone at the time of surgery. The product is designed as a **sustained-release protein biologic patch** intended to promote myocardial regeneration, improve contractile function, reduce scar burden, and prevent progression to heart failure after ischemic injury.

Brand names
EpicaPatch
Other names
rhFSTL1-containing collagen matrixrhFSTL-1-containing collagen matrixrhFSTL 1-containing collagen matrixhgFSTL1-containing compressed collagen matrixhgFSTL-1-containing compressed collagen matrixhgFSTL 1-containing compressed collagen matrixbioabsorbable rhFSTL1-containing collagen matrixepicardial biopharmaceutical
02

Targets

ACVR2B (Activin receptor type IIB)BMP4 (Bone morphogenetic protein 2)IDH1 (Isocitrate dehydrogenase [NADP] cytoplasmic)FSTL1 (Follistatin-like protein 1)TLR4 (Toll-like receptor 4)

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