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epicatechin-3-gallate
- Development stage
- Preclinical
- Lead developer
- Landeskrankenhaus
- Modality
- Small Molecules
- Administration
- Oral, Topical
01
Overview
Epicatechin-3-gallate (also known as epicatechin gallate or ECG) is a polyphenolic catechin abundant in green tea (*Camellia sinensis*). It is structurally similar to epigallocatechin-3-gallate (EGCG) and exhibits potent antioxidant, anti-inflammatory, and antineoplastic properties. ECG acts as a free radical scavenger and modulates various cellular signaling pathways, including the inhibition of matrix metalloproteinases (MMP-2 and MMP-9), aryl hydrocarbon receptor (AhR), cyclooxygenase-1 (COX-1), and glucose transporters (GLUT1 and GLUT5). Preclinical studies have investigated its potential in chemoprevention, cardiovascular diseases such as atherosclerosis, and as an antibacterial adjuvant against methicillin-resistant *Staphylococcus aureus* (MRSA).
- Other names
- (-)-epicatechin gallate(-)-epicatechin-3-gallate(-)-epicatechin-3-O-gallateECGepicatechin gallateepicatechin-3-O-gallateepicatechin3-O-gallateepicatechin 3-O-gallate
02
Targets
MMP9 (Matrix metalloproteinase-9)AHR (Aryl hydrocarbon receptor)CASP3 (Caspase-3)MMP2 (Matrix metalloproteinase-2)VEGFA (Vascular endothelial growth factor A)
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