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EpiCept-NP-1
- Development stage
- Unknown
- Lead developer
- EpiCept
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
EpiCept-NP-1 is a patented topical analgesic cream developed by EpiCept Corporation. It is a combination drug containing two FDA-approved drugs: 4% amitriptyline, a tricyclic antidepressant, and 2% ketamine, an NMDA receptor antagonist. This formulation was designed to provide effective, long-term relief from the pain associated with various peripheral neuropathies, including post-herpetic neuralgia (PHN), diabetic peripheral neuropathy (DPN), and chemotherapy-induced peripheral neuropathy (CPN). The topical route of administration aims to minimize systemic side effects and drug interactions.
- Brand names
- EpiCept NP-1
- Other names
- EpiCept™ NP-1 Topical Cream
02
Targets
SERT (Sodium-dependent serotonin transporter)NaV (Voltage-gated sodium channels)5-HT2 (5-HT2 receptor family)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)MOR (Mu opioid receptor)CaV (Voltage-gated calcium channel protein complex)NMDAR (Glutamate receptor ionotropic, NMDA)NET (Norepinephrine Transporter)ENT (Equilibrative nucleoside transporter family)AChR (Acetylcholine receptor)
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